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Because tizoxanide is highly protein bound (>99. ALINIA Tablets and ALINIA for Oral Suspension are contraindicated in patients with a prior hypersensitivity to nitazoxanide or any other ingredient in the formulations. Nitazoxanide is an antiprotozoal [ see Microbiology ]. Following oral administration of ALINIA Tablets or Oral Suspension, the parent drug, nitazoxanide, is not detected in plasma, norditropin nordiflex 15iu human growth hormone $150.00 norditropin. The pharmacokinetic parameners of the metabolites, tizoxanide and tizoxanide glucuronide are shown in Tables 2 and 3 below. Table 2: Mean (+/- SD) plasma pharmacokinetic parameters of tizoxanide and tizoxanide glucuronide following administration of a single dose of one 500 mg ALINIA Tablet with food to subjects ?12 years of age. Age Tizoxanide Tizoxanide Glucuronide Cmax (?g/mL) Tmax (hr) AUCt (?hr/mL) Cmax (?g/mL) Tmax (hr) AUCt (?g’hr/mL) 12 – 17 years 9. Age Tizoxanide Tizoxanide Glucuronide Dose Cmax (?g/mL) *Tmax (hr) AUCt (?hr/mL) C max (?g/mL) *T max (hr) AUC mf (?g’hr/mL) 1-3 years 100 mg 3. Following oral administration of a single ALINIA Tablet every 12 hours for 7 consecutive days, there was no significant accumulation of nitazoxanide metabolites tizoxanide or tizoxanide glucuronide detected in plasma. ALINIA for Oral Suspension is not bioequivalent to ALINIA Tablets. The relative bioavailability of the suspension compared to the tablet was 70%. When ALINIA Tablets are administered with food, the AUCt of tizoxanide and tizoxanide glucuronide in plasma is increased almost two-fold and the Cmax is increased by almost 50%. When ALINIA for Oral Suspension was administered with food, the AUCt of tizoxanide and tizoxanide glucuronide increased by about 45-50% and the Cmax increased by ?10%. 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