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Other serious side effects, explained in more detail below in ‘Side effect details,’ include: allergic reaction reduced bone mineral density (weakened bones) increased cholesterol level. You may wonder how often certain side effects occur with this drug. Here’s some detail on several of the side effects this drug may cause. For the side effects described below, results from clinical studies of women with either early breast cancer or advanced breast cancer are shown. With early breast cancer, the cancer hasn’t spread out of either your breast or the lymph nodes in your armpit. But with advanced breast cancer, the cancer has either spread to nearby areas or lymph nodes (called locally advanced breast cancer) or spread to other parts of your body (called metastatic breast cancer). As with most drugs, some people can have an allergic reaction after taking Arimidex. But it’s not known how often this occurs in people using Arimidex. Symptoms of a mild allergic reaction can include: skin rash itchiness flushing (warmth and redness in your skin) A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include: swelling under your skin, typically in your eyelids, lips, hands, or feet swelling of your tongue, mouth, or throat trouble breathing. Call your doctor right away if you have a severe allergic reaction to Arimidex. Call 911 if your symptoms feel life threatening or if you think you’re having a medical emergency. Reduced bone mineral density. It’s possible to have reduced bone mineral density (weakened bones) with Arimidex treatment. Estrogen helps to keep your bones strong. But Arimidex lowers your estrogen levels. This means the drug can weaken your bones and increase your risk of osteoporosis (thin, weak bones) or bone fractures. But keep in mind that the increased risk of breaking a bone goes away after you stop taking Arimidex. In a clinical study of women with early breast cancer who took Arimidex for 5 years, 11% developed osteoporosis. And 10% of the women taking Arimidex had bone fractures. In comparison, of women who took the cancer drug tamoxifen for 5 years, 7% had osteoporosis. And 7% of the women had a bone fracture. Your doctor may check your bone mineral density both before you start Arimidex and during your treatment, anabolic night. Checking your bone mineral density is how your doctor measures how strong your bones are. To do this, your doctor will order a type of X-ray test called a DEXA scan.
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