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So anything that’s used to treat arthritis pain that causes cartilage to die-off is a bad therapy. We’ve known for a LONG time that steroid shots destroy cartilage. In fact, the first paper on steroid shot side effects was in 1951! Steroid Shot Side Effects Chapter 2: Increasing Risk of Infection or Joint Replacement. It’s hard to imagine that a simple steroid shot in a joint could increase your risk for a joint infection if you need a joint replacement, but this is a real thing. In addition, it’s equally hard to imagine that this shot could make you more likely to need a joint replacement if you have arthritis. Let’s dig into what we know. We’ve also known for quite some time that patients who get steroid shots for various types of joint pain or arthritis are at higher risk for infection if they get a joint replacement at some point down the road (3). This is a thing not only for knees but also for hips as well (5). We also know that getting a steroid shot to help knee arthritis pain can increase the likelihood of needing a knee replacement, meaning the shot causes more knee cartilage breakdown (2). Hence, steroid shot side effects include increasing the risk for a joint replacement complication or for needing one in the first place. How big a deal is an infected knee or hip replacement? The average patient will need 6-12 weeks of IV antibiotics through a catheter inserted to a spot near the heart. For some patients, this won’t be enough to heal the infection and instead, they’ll have to have their infected joint ripped out and a new one implanted. Steroid Shot Side Effects Chapter 3: Systemic Problems. While the local impacts of steroid shots are quite real and devastating, there are also impacts on the whole body. The steroids injected into joints and tendons are at high enough dose that they leach into many parts of the body. Hence, steroid shot side effects can include problems with bone repair, the endocrine system, and blood sugar. For example, one study demonstrated that steroids used in epidural injections for back pain worsened osteoporosis in women (4). The same type of steroid shots also mess with the cortisol endocrine system that helps to keep you healthy (6). Finally, getting your knee joint injected also messes with your blood sugar, causing it to increase (12), Join us for a free Regenexx webinar. Steroid Shot Side Effects Chapter 4: New Research. We’ve known for a while that steroid shot side effects include problems with shoulder rotator cuff healing. For example, in one study measuring the healing blood vessels that grow into shoulder rotator cuff tears, patients who had steroid shots had fewer new blood vessels (10). In another, tendon cells in patients getting steroid shots were injured by the medication (13), oral steroid wash.
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