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Not surprisingly, supplements touted to increase GH release containing L-arginine came on the market. One study of arginine showed that a dose of 250 milligrams per kilogram of bodyweight for one week given to five young men increased the slow-wave sleep release of GH by 24 percent (GH is secreted at maximum levels during stage-4, or slow-wave, sleep). The problem here is that the dose is massive’more than 22 grams of arginine. Studies that show an arginine-based release of GH via the intravenous route use an average dose of 30 grams. Taking more than 10 grams of oral arginine at once often results in nausea. Other studies have shown that a combination of arginine and acetyl-L-carnitine can also boost GH. Other amino acids, including L-tryptophane, have led to increases in GH as well. One study showed that a dose of three grams of GABA, an amino acid product, increased both resting and exercise-related GH release. The problem here is that GABA is the primary inhibitory neurotransmitter in the brain, which means that it slows down brain function. In fact, most prescription sleeping pills are based on interactions with GABA receptors in the brain. Clearly, taking in something that puts you to sleep would not make for a very intensive training session. A recent study featuring 15 young men, all of whom had weight-training experience, examined the effects of a combination of two natural ingredients touted to boost GH, steroids for massive muscle growth. Chlorophytum borivilianum is an herb popular in Ayuvedic medicine, which has brought us some other useful herbs, such as guggulesterone. Chlorophytum borivilianum is alleged to boost immune response, help prevent cancer, reduce joint pain and even work as an aphrodisiac. It may also lower fats in the blood, which would have a beneficial effect on GH release. Velvet bean has previously been used in supplements to boost GH. The key to velvet bean is its content of L-dopa, an amino acid that is converted in the body into dopamine, a major brain neurotransmitter. Many of the current stimulant supplements work by also boosting dopamine in the brain, which stimulates work output and produces an energized feeling. It’s no coincidence that both cocaine and methamphetamine also boost brain dopamine. L-Dopa itself has been shown in several studies to have the ability to boost GH release. The subjects took the supplement on two different days, separated by one week. The researchers collected blood from the men before they took the supplement and at 20, 40, 60, 80 and 120 minutes after they took it. The results showed a gradual rise in GH, with increases at the 60-, 80- and 100-minute marks, but there was also a great amount of variability in the response of the subjects, with some of the men producing far more GH than others. Various factors could explain such differences, such as bodyfat levels, age and exercise intensity, although how those factors may have affected the supplement response wasn’t discussed in the study. In addition, the capsules used in the study varied in their inactive-ingredients content, which also could have affected the response.
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